It was announced on the 1st May 2019 that S-cubed has acquired A3 Informatics. Future information and updates can be found there. 


A3 Informatics Today

The Glandon MDR can today manage sponsor and CDISC standards including terminology, forms (CDASH) and SDTM. In addition, the system manages Biomedical Concepts to allow for a flexible way to build more standardised forms and capture data consistently across studies. The system provides version control, giving instant access to changes across versions and provides impact analysis processing when new versions are created.
The Glandon Study Workbench is a tool for specifying what data to collect and report for a study. The latest version integrates study build and define.xml functionality. The tool utilises the metadata from the Glandon MDR and the relationships between the metadata. The user can build a Schedule of Assessments (SoA), create study CRFs and aCRFs, export definitions to EDC systems using ALS or ODM and create a define.xml for the study


To support the move away from a variable-based world to one based on real-world concepts and the data’s natural form with associated relationships  (Biomedical Concepts). This move is needed to address issues faced by industry in the use of data standards today.


Use semantic web and graph technologies to provide the underlying model.

The use of these technologies allows for new areas to be easily accommodated and updates made without major disruption to existing work. Thus, as standards evolve, so can the tools without disrupting users.


The Glandon Suite will support the full clinical lifecycle with an MDR that supports tools across that lifecycle. It utilises an open system using an API that allows for individual tools.

Today the system supports study setup. During Q4 of 2018 support for ADaM and in 2019 support for basic protocol definitions to be introduced.

Glandon MDR

The Glandon MDR is a Metadata Repository handling CDISC Terminology (version control and management), Biomedical Concepts, Forms and SDTM  Model, Implementation Guides and Custom Domains

Glandon Study Workbench

A tool that takes definitions from the MDR and allows studies to be constructed and then exported in ODM and ALS formats suitable for loading by EDC tools.


A Chance to Change – Reflections on CDISC and PhUSE

Dave Iberson-Hurst reflects on the events of the past months. Over the last month or so, I have attended both the CDISC European Interchange in Berlin and the PhUSE Inaugural US Connect Conference in North Carolina. At both events, I have had quite a few chats and...

Removing Silos: Leveraging CDISC Standards

Data silos challenges study setup & implementing CDISC Standards - The Glandon Suite offers the solution Setting up a new study presents users of the CDISC standards with a number of challenges including study build, managing the transformations needed to get from...

On Fire at the CDISC Interchange

A3 Informatics stepped out at the CDISC European Interchange in Berlin for the first time, at the end of April and it proved to be a very busy and successful event. Both Dave Iberson-Hurst and Johannes Ulander were presenting and you can read more and download their...